Targeting DNA Methylation

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Targeting DNA methylation.

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Development of methods that will allow exogenous imposition of inheritable gene-specific methylation patterns has potential application in both therapeutics and in basic research. An ongoing approach is the use of targeted DNA methyltransferases, which consist of a fusion between gene-targeted zinc-finger proteins and prokaryotic DNA cytosine methyltransferases. These enzymes however have so fa...

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ژورنال

عنوان ژورنال: Clinical Cancer Research

سال: 2009

ISSN: 1078-0432,1557-3265

DOI: 10.1158/1078-0432.ccr-08-2783